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The journal of 'CardioRenal Medicine' explores the mechanisms by which obesity and other metabolic abnormalities promote the pathogenesis and progression of heart and kidney disease (cardiorenal metabolic syndrome). It provides an interdisciplinary platform for the advancement of research and clinical practice, focussing on translational issues.
Attention is paid to the fact that some metabolic abnormalities cluster with heart and chronic kidney disease, and collectively this is called the cardiorenal metabolic syndrome. Moreover, certain metabolic abnormalities of the heart promote impaired coronary artery endothelial function, diastolic dysfunction and ischemic reconditioning that parallel glomerular hyperfiltration and impairments in proximal tubule handling of sodium and albumin. Another point of focus is the role of the obesity epidemic in promoting the increasing incidence of heart and kidney disease in industrialized countries and the prevailing problems of insufficient exercise and excessive consumption of cheap, unwholesome food in promotion of the cardiorenal metabolic syndrome in both adults and children.
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